I did the fresh install MacOS Big Sur on my MacBook15 inch(2017) today. I then downloaded and installed Unipro UGENE v. 36. The installation finished just fine, but When I called the the Unipro UGENE, it did not load any things (did not response).
Anyone has the same problem as me?
"Date/Time: 2020-11-14 17:22:37.317 +0700
End time: 2020-11-14 17:47:58.812 +0700
OS Version: macOS 11.0.1 (Build 20B29)
Architecture: x86_64h
Report Version: 32
Data Source: Stackshots
Shared Cache: 9F6FFF1F-4096-355B-B037-8DCE73A7AA42 slid base address 0x7fff20008000, slide 0x8000
Command: ugeneui
Path: /Applications/Unipro UGENE.app/Contents/MacOS/ugeneui
Version: ??? (???)
Parent: launchd [1]
PID: 1028
Time Since Fork: 1533s
Event: hang
Duration: 1521.50s
Duration Sampled: 1.10s (process was unresponsive for 1520 seconds before sampling)
Steps: 11 (100ms sampling interval)
Hardware model: MacBookPro14,3
Active cpus: 8
Time Awake Since Boot: 2745s
Time Since Wake: 1540s
Fan speed: 5596 rpm
--------------------------------------------------
Timeline format: stacks are sorted chronologically
Use -i and -heavy to re-report with count sorting
--------------------------------------------------
Heaviest stack for the main thread of the target process:
11 start + 1 (libdyld.dylib + 87601) [0x7fff20330631]
11 main + 18328 (ugeneui + 50984) [0x105cfa728]
11 QCoreApplication::exec() + 130 (QtCore + 2009394) [0x108a88932]
11 QEventLoop::exec(QFlags<QEventLoop:

rocessEventsFlag>) + 431 (QtCore + 1988927) [0x108a8393f]
11 ??? (libqcocoa.dylib + 220494) [0x10ed96d4e]
11 -[NSApplication(NSEvent) _nextEventMatchingEventMask:untilDate:inMode:dequeue:] + 1366 (AppKit + 251723) [0x7fff22c2374b]
11 _DPSNextEvent + 883 (AppKit + 257925) [0x7fff22c24f85]
11 _BlockUntilNextEventMatchingListInModeWithFilter + 64 (HIToolbox + 199407) [0x7fff28677aef]
11 ReceiveNextEventCommon + 709 (HIToolbox + 200140) [0x7fff28677dcc]
11 RunCurrentEventLoopInMode + 292 (HIToolbox + 200656) [0x7fff28677fd0]
11 CFRunLoopRunSpecific + 563 (CoreFoundation + 521918) [0x7fff2040b6be]
11 __CFRunLoopRun + 838 (CoreFoundation + 524509) [0x7fff2040c0dd]
11 __CFRunLoopDoObservers + 549 (CoreFoundation + 527405) [0x7fff2040cc2d]
11 __CFRUNLOOP_IS_CALLING_OUT_TO_AN_OBSERVER_CALLBACK_FUNCTION__ + 23 (CoreFoundation + 527773) [0x7fff2040cd9d]
11 ___NSRunLoopObserverCreateWithHandler_block_invoke + 41 (AppKit + 9493774) [0x7fff234f3d0e]
11 __62+[CATransaction(NSCATransaction) NS_setFlushesWithDisplayLink]_block_invoke + 285 (AppKit + 1849803) [0x7fff22da99cb]
11 CA::Transaction::commit() + 783 (QuartzCore + 12177) [0x7fff26b92f91]
11 CA::Context::commit_transaction(CA::Transaction*, double, double*) + 517 (QuartzCore + 1438579) [0x7fff26cef373]
11 CA::Layer::display_if_needed(CA::Transaction*) + 874 (QuartzCore + 153016) [0x7fff26bb55b8]
10 -[_NSViewBackingLayer display] + 555 (AppKit + 1152888) [0x7fff22cff778]
10 -[_NSBackingLayer display] + 475 (AppKit + 1763233) [0x7fff22d947a1]
10 -[CALayer display] + 183 (QuartzCore + 154890) [0x7fff26bb5d0a]
10 ??? (libqcocoa.dylib + 160590) [0x10ed8834e]
10 ??? (libqcocoa.dylib + 126332) [0x10ed7fd7c]
10 void QWindowSystemInterface::handleExposeEvent<QWindowSystemInterface::SynchronousDel
ivery>(QWindow*, QRegion const&) + 178 (QtGui + 118978) [0x107fc00c2]
10 bool QWindowSystemInterfacePrivate::handleWindowSystemEvent<QWindowSystemInterface::S
ynchronousDelivery>(QWindowSystemInterfacePrivate::WindowSystemEvent*) + 115 (QtGui + 90339) [0x107fb90e3]
10 QGuiApplicationPrivate::processExposeEvent(QWindowSystemInterfacePrivate::Expose
Event*) + 309 (QtGui + 229653) [0x107fdb115]
10 QCoreApplication::notifyInternal2(QObject*, QEvent*) + 212 (QtCore + 2007844) [0x108a88324]
10 QApplication::notify(QObject*, QEvent*) + 594 (QtWidgets + 72322) [0x107a0ea82]
10 QApplicationPrivate::notify_helper(QObject*, QEvent*) + 269 (QtWidgets + 67197) [0x107a0d67d]
10 ??? (QtWidgets + 436548) [0x107a67944]
10 ??? (QtWidgets + 447940) [0x107a6a5c4]
10 ??? (QtWidgets + 117410) [0x107a19aa2]
10 ??? (QtWidgets + 100334) [0x107a157ee]
10 QBackingStore::flush(QRegion const&, QWindow*, QPoint const&) + 1207 (QtGui + 1838887) [0x108163f27]
4 ??? (libqcocoa.dylib + 83880) [0x10ed757a8]
4 QMacAutoReleasePool::~QMacAutoReleasePool() + 40 (QtCore + 2933224) [0x108b6a1e8]
4 -[NSAutoreleasePool drain] + 129 (Foundation + 212481) [0x7fff21169e01]
4 _CFAutoreleasePoolPop + 22 (CoreFoundation + 270816) [0x7fff203ce1e0]
4 objc_autoreleasePoolPop + 161 (libobjc.A.dylib + 33598) [0x7fff201b433e]
4 AutoreleasePoolPage::releaseUntil(objc_object**) + 167 (libobjc.A.dylib + 152477) [0x7fff201d139d]
3 -[NSImageArrayRepProvider dealloc] + 22 (AppKit + 10344965) [0x7fff235c3a05]
2 -[__NSSingleObjectArrayI dealloc] + 57 (CoreFoundation + 288952) [0x7fff203d28b8]
2 -[NSCGImageSnapshotRep dealloc] + 28 (AppKit + 1837167) [0x7fff22da686f]
1 _CFRelease + 1147 (CoreFoundation + 1359993) [0x7fff204d8079]
1 malloc_zone_free + 6 (libsystem_malloc.dylib + 33231) [0x7fff201421cf]
Process: ugeneui (Unipro UGENE) [1028]
UUID: A46D073A-55DF-3239-8F28-30AD73B714F5
Path: /Applications/Unipro UGENE.app/Contents/MacOS/ugeneui
Architecture: x86_64
Parent: launchd [1]
UID: 501
Footprint: 3625.17 MB
Time Since Fork: 1533s
Num samples: 11 (1-11)
CPU Time: 0.994s (3.5G cycles, 3.4G instructions, 1.01c/i)
Note: Unresponsive for 1520 seconds before sampling
Note: 1 idle work queue thread omitted
Thread 0x4aef DispatchQueue "com.apple.main-thread"(1) 11 samples (1-11) priority 46 (base 46) cpu time 0.993s (3.5G cycles, 3.4G instructions, 1.01c/i)
<thread QoS user interactive (requested user interactive), process unclamped, process received importance donation from WindowServer [136], IO tier 0>
11 start + 1 (libdyld.dylib + 87601) [0x7fff20330631] 1-11
11 main + 18328 (ugeneui + 50984) [0x105cfa728] 1-11
11 QCoreApplication::exec() + 130 (QtCore + 2009394) [0x108a88932] 1-11
11 QEventLoop::exec(QFlags<QEventLoop:

rocessEventsFlag>) + 431 (QtCore + 1988927) [0x108a8393f] 1-11
11 ??? (libqcocoa.dylib + 220494) [0x10ed96d4e] 1-11
11 -[NSApplication(NSEvent) _nextEventMatchingEventMask:untilDate:inMode:dequeue:] + 1366 (AppKit + 251723) [0x7fff22c2374b] 1-11
11 _DPSNextEvent + 883 (AppKit + 257925) [0x7fff22c24f85] 1-11
11 _BlockUntilNextEventMatchingListInModeWithFilter + 64 (HIToolbox + 199407) [0x7fff28677aef] 1-11
11 ReceiveNextEventCommon + 709 (HIToolbox + 200140) [0x7fff28677dcc] 1-11
11 RunCurrentEventLoopInMode + 292 (HIToolbox + 200656) [0x7fff28677fd0] 1-11
11 CFRunLoopRunSpecific + 563 (CoreFoundation + 521918) [0x7fff2040b6be] 1-11
11 __CFRunLoopRun + 838 (CoreFoundation + 524509) [0x7fff2040c0dd] 1-11
11 __CFRunLoopDoObservers + 549 (CoreFoundation + 527405) [0x7fff2040cc2d] 1-11
11 __CFRUNLOOP_IS_CALLING_OUT_TO_AN_OBSERVER_CALLBACK_FUNCTION__ + 23 (CoreFoundation + 527773) [0x7fff2040cd9d] 1-11
11 ___NSRunLoopObserverCreateWithHandler_block_invoke + 41 (AppKit + 9493774) [0x7fff234f3d0e] 1-11
11 __62+[CATransaction(NSCATransaction) NS_setFlushesWithDisplayLink]_block_invoke + 285 (AppKit + 1849803) [0x7fff22da99cb] 1-11
11 CA::Transaction::commit() + 783 (QuartzCore + 12177) [0x7fff26b92f91] 1-11
11 CA::Context::commit_transaction(CA::Transaction*, double, double*) + 517 (QuartzCore + 1438579) [0x7fff26cef373] 1-11
11 CA::Layer::display_if_needed(CA::Transaction*) + 874 (QuartzCore + 153016) [0x7fff26bb55b8] 1-11
7 -[_NSViewBackingLayer display] + 555 (AppKit + 1152888) [0x7fff22cff778] 1-7
7 -[_NSBackingLayer display] + 475 (AppKit + 1763233) [0x7fff22d947a1] 1-7
7 -[CALayer display] + 183 (QuartzCore + 154890) [0x7fff26bb5d0a] 1-7
7 ??? (libqcocoa.dylib + 160590) [0x10ed8834e] 1-7
7 ??? (libqcocoa.dylib + 126332) [0x10ed7fd7c] 1-7
7 void QWindowSystemInterface::handleExposeEvent<QWindowSystemInterface::SynchronousDel
ivery>(QWindow*, QRegion const&) + 178 (QtGui + 118978) [0x107fc00c2] 1-7
7 bool QWindowSystemInterfacePrivate::handleWindowSystemEvent<QWindowSystemInterface::S
ynchronousDelivery>(QWindowSystemInterfacePrivate::WindowSystemEvent*) + 115 (QtGui + 90339) [0x107fb90e3] 1-7
7 QGuiApplicationPrivate::processExposeEvent(QWindowSystemInterfacePrivate::Expose
Event*) + 309 (QtGui + 229653) [0x107fdb115] 1-7
7 QCoreApplication::notifyInternal2(QObject*, QEvent*) + 212 (QtCore + 2007844) [0x108a88324] 1-7
7 QApplication::notify(QObject*, QEvent*) + 594 (QtWidgets + 72322) [0x107a0ea82] 1-7
7 QApplicationPrivate::notify_helper(QObject*, QEvent*) + 269 (QtWidgets + 67197) [0x107a0d67d] 1-7
7 ??? (QtWidgets + 436548) [0x107a67944] 1-7
7 ??? (QtWidgets + 447940) [0x107a6a5c4] 1-7
7 ??? (QtWidgets + 117410) [0x107a19aa2] 1-7
7 ??? (QtWidgets + 100334) [0x107a157ee] 1-7
7 QBackingStore::flush(QRegion const&, QWindow*, QPoint const&) + 1207 (QtGui + 1838887) [0x108163f27] 1-7
1 ??? (libqcocoa.dylib + 83880) [0x10ed757a8] 1
1 QMacAutoReleasePool::~QMacAutoReleasePool() + 40 (QtCore + 2933224) [0x108b6a1e8] 1
1 -[NSAutoreleasePool drain] + 129 (Foundation + 212481) [0x7fff21169e01] 1
1 _CFAutoreleasePoolPop + 22 (CoreFoundation + 270816) [0x7fff203ce1e0] 1
1 objc_autoreleasePoolPop + 161 (libobjc.A.dylib + 33598) [0x7fff201b433e] 1
1 AutoreleasePoolPage::releaseUntil(objc_object**) + 167 (libobjc.A.dylib + 152477) [0x7fff201d139d] 1
1 -[NSInvocation dealloc] + 124 (CoreFoundation + 411151) [0x7fff203f060f] 1
1 -[__NSArrayM dealloc] + 279 (CoreFoundation + 140948) [0x7fff203ae694] 1
1 __RELEASE_OBJECTS_IN_THE_ARRAY__ + 118 (CoreFoundation + 141137) [0x7fff203ae751] 1
1 _CFRelease + 244 (CoreFoundation + 1359090) [0x7fff204d7cf2] 1
1 __CFDataDeallocate + 91 (CoreFoundation + 141627) [0x7fff203ae93b] 1
1 free_tiny + 442 (libsystem_malloc.dylib + 25081) [0x7fff201401f9] 1
1 tiny_free_no_lock + 1116 (libsystem_malloc.dylib + 26538) [0x7fff201407aa] 1
1 tiny_free_list_add_ptr + 404 (libsystem_malloc.dylib + 28238) [0x7fff20140e4e] 1
*1 ??? (kernel + 671792) [0xffffff80002b4030] (runnable) 1
1 ??? (libqcocoa.dylib + 83789) [0x10ed7574d] 2
1 ??? (libqcocoa.dylib + 84857) [0x10ed75b79] 2
1 -[NSObject(NSObject) methodSignatureForSelector:] + 30 (CoreFoundation + 603636) [0x7fff2041f5f4] 2
1 __methodDescriptionForSelector + 128 (CoreFoundation + 496918) [0x7fff20405516] 2
1 protocol_getMethodDescription + 52 (libobjc.A.dylib + 51146) [0x7fff201b87ca] (running) 2
1 ??? (libqcocoa.dylib + 83880) [0x10ed757a8] 3
1 QMacAutoReleasePool::~QMacAutoReleasePool() + 40 (QtCore + 2933224) [0x108b6a1e8] 3
1 -[NSAutoreleasePool drain] + 129 (Foundation + 212481) [0x7fff21169e01] 3
1 _CFAutoreleasePoolPop + 22 (CoreFoundation + 270816) [0x7fff203ce1e0] 3
1 objc_autoreleasePoolPop + 161 (libobjc.A.dylib + 33598) [0x7fff201b433e] 3
1 AutoreleasePoolPage::releaseUntil(objc_object**) + 167 (libobjc.A.dylib + 152477) [0x7fff201d139d] 3
1 -[NSImageArrayRepProvider dealloc] + 22 (AppKit + 10344965) [0x7fff235c3a05] 3
1 -[__NSSingleObjectArrayI dealloc] + 57 (CoreFoundation + 288952) [0x7fff203d28b8] 3
1 -[NSCGImageSnapshotRep dealloc] + 28 (AppKit + 1837167) [0x7fff22da686f] 3
1 _CFRelease + 244 (CoreFoundation + 1359090) [0x7fff204d7cf2] 3
1 image_finalize + 50 (CoreGraphics + 466122) [0x7fff24f4ecca] 3
1 free + 0 (libsystem_malloc.dylib + 8380) [0x7fff2013c0bc] (running) 3
1 ??? (libqcocoa.dylib + 82019) [0x10ed75063] 4
1 -[NSView lockFocusIfCanDraw] + 192 (AppKit + 3148046) [0x7fff22ee690e] 4
1 CGContextCreateWithDelegateAndInfo + 162 (CoreGraphics + 123234) [0x7fff24efb162] 4
1 CGGStackCreateWithGState + 20 (CoreGraphics + 124453) [0x7fff24efb625] 4
1 _malloc_zone_malloc + 118 (libsystem_malloc.dylib + 114174) [0x7fff20155dfe] 4
1 szone_malloc_should_clear + 66 (libsystem_malloc.dylib + 10131) [0x7fff2013c793] 4
1 tiny_malloc_should_clear + 971 (libsystem_malloc.dylib + 15192) [0x7fff2013db58] (running) 4
1 ??? (libqcocoa.dylib + 82362) [0x10ed751ba] 5
1 _CFRelease + 244 (CoreFoundation + 1359090) [0x7fff204d7cf2] 5
1 image_finalize + 50 (CoreGraphics + 466122) [0x7fff24f4ecca] 5
1 CGNotificationCenterPostNotification + 67 (CoreGraphics + 466637) [0x7fff24f4eecd] 5
1 pthread_mutex_lock + 52 (libsystem_pthread.dylib + 7627) [0x7fff20310dcb] (running) 5
1 ??? (libqcocoa.dylib + 82417) [0x10ed751f1] 6
1 -[NSImage initWithCGImage:size:] + 312 (AppKit + 1592070) [0x7fff22d6ab06] 6
1 -[NSCGImageSnapshotRep initWithCGImage:drawingRect:applicableForRect:context:hints:] + 314 (AppKit + 1592437) [0x7fff22d6ac75] 6
1 -[NSSnapshotContextSignature initWithDrawingRect:applicableForRect:context:hints:] + 461 (AppKit + 1592983) [0x7fff22d6ae97] 6
1 +[NSAppearance currentAppearance] + 14 (AppKit + 179856) [0x7fff22c11e90] 6
1 __NSAppKitGetThreadSpecificData + 89 (AppKit + 73111) [0x7fff22bf7d97] (running) 6
1 ??? (libqcocoa.dylib + 83880) [0x10ed757a8] 7
1 QMacAutoReleasePool::~QMacAutoReleasePool() + 40 (QtCore + 2933224) [0x108b6a1e8] 7
1 -[NSAutoreleasePool drain] + 129 (Foundation + 212481) [0x7fff21169e01] 7
1 _CFAutoreleasePoolPop + 22 (CoreFoundation + 270816) [0x7fff203ce1e0] 7
1 objc_autoreleasePoolPop + 161 (libobjc.A.dylib + 33598) [0x7fff201b433e] 7
1 AutoreleasePoolPage::releaseUntil(objc_object**) + 167 (libobjc.A.dylib + 152477) [0x7fff201d139d] 7
1 -[NSImageArrayRepProvider dealloc] + 22 (AppKit + 10344965) [0x7fff235c3a05] 7
1 -[__NSSingleObjectArrayI dealloc] + 87 (CoreFoundation + 288982) [0x7fff203d28d6] 7
1 free_tiny + 442 (libsystem_malloc.dylib + 25081) [0x7fff201401f9] 7