No, is trying to connect to this database:
http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtmlThen is a connectivity problem, you are not having access to internet from UGENE. Check if the firewall is blocking UGENE.
As a simple test, go to Help/Check for Updates. If nothing happens, see the log (bottom left). If I do that without connection I get this:
[10:10][ERROR] Task {Check for updates} finished with error: Connection error: Host ugene.unipro.ru not found
Otherwise you should get a messagebox showing your current version and the latest available.